Updated Genetic Maps Description

There are now over 800 polymorphic markers identified that map to human chromosome 1. Identifying and presenting the map locations of all markers has presented substantial challenges.

The initial goal of this project was to create a Comprehensive Positional map by localizing all markers against a backbone consisting of the 1996 Genethon linkage map of chromosome 1. 126 markers were chosen to represent each map position in the Genethon map. This backbone map is presented in the list below. Next, all remaining chromosome 1 markers were mapped relative to this backbone. Between the CEPH 8.0 database and a few other resources, I was able to identify ~690 additional markers. This number remains unclear since some markers are quite old and I can no longer find them in any current database, and a few markers may not actually map to chromosome 1.

The MultiMap and CRI-MAP computer programs were used to map these markers. A lod score of 3 or odds of at least 1000:1 were used. At this level of support, some markers clearly map to only one backbone map interval, while others map to two or more intervals. The relative likelihoods for all markers are available from the list below.

The entire map has been drawn in a graphical format and is available below for you to download and view or print. It will be available soon at GDB, which is developing a new JAVA-based map viewer that will provide a useful format for viewing the map. For now only test-based information is available on this web page.

An additional goal of this project is to improve the map resolution by adding markers to the Genethon backbone wherever possible. This would constitute a Comprehensive Expanded map. The 1000:1 odds expanded map which includes 154 uniquely ordered markers took several days to complete due to the large number of markers. I am working on a 100:1 odds map, using the map of 154 markers as a starting framework, and agin, this will take some time to complete.

In addition, it is possible to compute refined maps for smaller chromosomal regions or focusing on small subsets of markers. The genotypes are all available from CEPH v8.0, so you can pursue such mapping endeavors on your own or can consider a collaboration with me - send e-mail.