Genetic Map Figure Legend

• The map backbone is shown on the left. It is comprised of 126 Genethon markers whose order is known with odds > 1000:1. The distances are given in Kosambi centiMorgans (cM).

   

• The off-backbone markers are shown in the right. Genes are drawn in Red , PCR-based markers are drawn in Blue, and Hybridization-based markers are drawn in Green.

   

• The off-backbone markers are shown next to their 1000:1 odds support interval. This interval may span one or several backbone intervals. When multiple markers are shown next to the same interval, their relative order is NOT KNOWN. Boxes have been drawn around some such clusters to clearly separate them from neighboring intervals.

   

• The bar spanning the off-backbone marker intervals may be a thick bar, or it may have both a thin and a thick section. The thick sections indicate the more likely interval(s) of the overall support interval.

   

• Example: the support interval for a marker spans only 1 backbone interval, it will be thick and indicates that the marker maps only to that single interval with odds > 1000:1. If the map were being expanded to add more markers, this marker could be added to that map interval.

   

• Example: the support interval for a marker spans 2 backbone intervals, and the spanning bar is half thick and half thin. This indicates that the odds for the marker lying in either one of the 2 intervals are less than 1000:1 and we conclude only that the marker lies somewhere in either interval. The thick bar indicates the more likely of the two intervals. Suppose the backbone markers are A-B-C and our marker lies either in interval A-B or in B-C. Let the odds be 100:1 (LOD score = 2.0) that the marker is in A-B and 500:1 (LOD score = 2.7) that the marker lies in B-C. Thus, the marker is 5 times more likely to lie in B-C than in A-B, and the bar spanning B-C will be thick while the bar spanning A-B will be thin.

   

• Example: the support interval for a marker spans 2 backbone intervals and is thick in both intervals. This indicates that the marker is as likely to lie in one intervals as in the other.