Marker Descriptions and Notes

In pulling together a set of markers as large as this one, originally with 869 markers representing ~825 loci, it is inevitable that one will encounter some unusual markers - perhaps some that actually map to a different chromosome, some that don't map very well though they are linked to chromosome 1, and some older markers on which no information is currently available. I'll briefly descibe these here.

With regard to locus names, I was careful to use only names approved by the GDB nomenclature committee. Please let me know if you find some that are incorrectly identified. 

• The marker D1S3669 is also called D2S1368. It is linked to several marker on chromosome 1 so the D2 number should probably be inactivated at GDB.

   

• These markers are available in CEPH v8.0 but are not in GDB and I cannot find any information on them. They are not shown on the map figure since it will be submitted to GDB and only markers already in GDB can be allowed. Please contact me if you can help. They are all hybridization-based markers. AFM234,CAATP3, COS161C3/CEB98, EMBL-11, GLY or GLY10, p2210RD,RLK.

   

• These 2 CHLC markers are not in GDB and do not have D-numbers, so again, are not on the map figure: GATA25,GCT1C9.

   

• These markers are probably on chromosome 1, but were not genotyped in any of the same 8 pedigrees that the Genethon backbone markers were genotyped in. Therefore they cannot be placed on this map: D1S20, LOR (Loricrin), D1S153, D1S34.

   

• These markers are in the CEPH v8.0 file but do not have a lod score of at least 3.0 with any of the backbone markers. Thus, this data does not show them to be linked to chromosome 1, and they are not shown on the map figure: HZ50, ERLP1, D1S90.

   

• These markers are linked to chromosome 1 but couldn't be localized to any one region of the chromosome using the available genotyping data. Therefore they are not shown on the map figure: HTR1D, D1S81, D1S2133, D1S1184, PGD, D1S41, D1S1605, D1S176, D1S1182, D1S1643, D1S3473, D1S91, D1S164, D1S164, D1S520, Sele (Selectin)