I have a 9 year old daughter diagnosed with a chromosome 1
translocated to chromosome 9. Trying to find any information
on the subject. Can you point me in the right direction on
information.

Thank you
David Baxter
dbaxter@cris.com

I am performing linkage studies on the distal arm of
chromosome 1. The distal most genetic marker I have
identified is D1S468. Is anyone aware of additional
markers that can be used in linkage analysis (preferably
small nucleotide repeats) in this region?

Thanks.

I have recently been working in the 1p36 region, and I have encountered some difficulties in hitting YACs with certain markers that should be positive according to the literature. Have any of you had problems with the markers D1S160, D1S450, or D1S228? I am assuming it is in part due to the poor coverage of the region, but if anybody has some insights into working around this problem, I would apreciate it.

Thanks,

Eric Benoit

Now I am trying to clone a fragment from Chr.1 which is
supposed to be a promoter region of a cloned gene. I am
wondering if you can heip me search the updated sequence
data of Chr.1 to see if this fragement has been sequenced.
That will be a great help.
Hope to hear your reply asap!
Sincerely,
long ma

CHROMOSOME 1 MAILING LIST

Announcing the creation of an electronic mailing list for human chromosome 1. This service is designed to serve the needs of the chromosome 1 mapping and sequencing community, as well as to promote discussion and data exchange in this area. This notice is being sent to all participants of the 2nd SCW1 workshop, to all individuals who posted comments on the chromosome 1 WWW discussion forum (http://linkage.cpmc.columbia.edu/chr1/), and to other known interested individuals. Please distribute this announcement to other interested parties.

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Thanks for your interest,

Pete White

Greetings,

One question and then a comments:

I am attempting to gather all the lengths of chromosome bands for the human
genome in one place. Do you have the band lengths in megabases for
chromosome 1, especially at the 850 band resolution,and are you willing to
share that data. The alternative is for me to messure the ideograms. Any
help in this area would be appreciated.

On the web pages, remove the scrolling banner at the bottom status bar; it
makes my browser core dump when it finishs it's message. Other than that,
great job.

Thanks again for any help you could give to me.

Robert Sutherland.

============================================================================
Robert Sutherland (CIC-12) \/ MS M880, Los Alamos, NM 87545
email: rds@lanl.gov < oo > phone: (505)665-0182
Center for Human Genome Studies | __ | fax: (505)665-3024
Los Alamos National Laboratory / \ http://www-ls.lanl.gov
============================================================================

I am interested in van der Woude syndrome, which maps to long arm of chromosome 1.

I just fund your page, and hope to get in contact with others
diving in 1p. I noted there might be a chr.1 meeting either
before or after the next ASHG meeting in San Francisco. I would
like to attend this meeting, and appreciate if you could send me
more information, and how to register.

Recently, I received a letter from Dr. Richard
Wooster who will be setting up a chromosome 1 mapping project
at the Sanger Centre in Cambrdge, UK. This letter may be of
interest to a number of mappers in the chromosome 1
community as Dr. Wooster seeks communication with such groups.
I am posting his letter here:

Dear Dr Weith

I will be starting work at the Sanger Centre near Cambridge
on 22 April 1996. The main focus of my work will be the
construction of a complete physical map for chromosome 1.
The map is likely to be made from bacterial clones (PACs,
BACs and cosmids) and it will be anchored to the Genebridge
radiation hybrid panel and to the Genetic map using known
polymorphic markers. The ultimate aim of this work will be
the sequencing of the chromosome.

The results of this project will be freely available to the
scientific community.

I noted in the report from the second Chromosome 1 workshop
that you were intending to have small meeting either before
or after the next ASHG meeting in San Francisco. If
possible, I would like to attend this meeting so that I can
inform those present on the strategy and likely time scale
of this work. Can you let me know if this will be possible?
I should have some initial results by then which I will be
able to present.

I will be more than willing to share any information during
this work. If I can be any more help, please let me know. I
would also be happy if yoy could pass this on to other
people who may be interested.

Best Wishes

Richard Wooster

_____________________________________________________________
Present address New Address

Dr Richard Wooster Sanger Centre
Haddow Labs Hinxton Hall
Institute of Cancer Research Hinxton
15 Cotswold Rd Cambs
Sutton, Surrey CB10 1RQ
SM2 5NG, UK UK
phone 0181 643 8901 01223 834244
fax 0181 770 7290 01223 494919
e-mail richw@icr.ac.uk

We have localised a gene, BRF2, to 1p36.1. This gene was formerly known as
ERF1, and specifies a protein with an unusual zinc finger
like motif characteristic of TIS11 family members. This motif
has been shown to bind zinc, at least one family member has
been localised to the nucleus, and another member has been
shown to be involved in the regulation of p34cdc2.
We have established no function for its gene product, as yet.
We have submitted this information for publication to Genomics.

I was wondering if anyone can suggest cell lines with (preferably homozygous) deletions encompassing 1p32.
I am trying to determine the function of a protein that maps there, and would like to get a knockout.
Any help would be great.
Thanks
Roy

I'm new to this area but very interested in the 1q20-24 region. I'd appreciate information on maps, markers, genes in this region. Thanks.