CHROMOSOME 1 WORKSHOP 2000 PROGRAM

PROGRAM WORKSHOP ABSTRACTS MEETING PARTICIPANTS WORKSHOP REPORT

The meeting consisted of five or six presentation sessions and two or three IT (Information Technology) sessions (depending on final number of participants).

The presentations were 15 minute slide/powerpoint talks with a few minutes for discussion. Participants were asked to bring a poster of their data to supplement their talks. While the posters were not mandatory for the meeting, the schedule included time between the sessions to view the posters. This time was used for more focused discussions.

The IT sessions gave the participants a chance to peruse the various online databases in the presence of experts. They included brief overviews of the sequencing information at Sanger and the integrated map of chromosome 1, CompView, developed at CHOP.

The schedule also included a 3 hour social activity and our final conference dinner was prepared by a Mennonite family on their farm.

Saturday, September 30

1600 -1800 Registration at the Sheraton Hotel

1800 -1900 Reception

1930 Dinner

Sunday, October 1

0830-0900: Introduction - Jeff Murray

0900-1030: Session 1 - GLOBAL

1.	Simon Gregory	Construction of a Human Chromosome 1 Physical and Transcription Map
2.	Bento Soares	Current status of the University of Iowa Mammalian Gene Discover Program
3.	Akira Horii	Construction of a BAC-based STS-content map spanning a 35-megabase region of 1p36-p35
4.	John Carpten	A detailed map of the 1q24-q31 region: The next step, sequence analysis

1030-1100: Posters - Coffee

1100-1230: IT Session (I)

1230-1330: Lunch

1330-1500: Session 2 - CANCER (1p36)

5.	Miki Ohira	Identification and characterization of the 500 kb homozygously deleted region at 1p36.2-p36.3 in neuroblastoma
6.	Tommy Martinsson	Apoptotic key player Caspase-9 (CASP9), located in 1p36.2-3
7.	Shi Huang	Mapping of a minimal deleted region on 1p36 in endocrine tumors of the parathyroid and adrenal medulla
8.	Matt McDonald	Gene expression profiling of oligodendrogliomas
9.	Carl Malchoff	The syndrome of Familial Papillary Thyroid Carcinoma with Papillary Renal Neoplasia (fPTC/PRN) is a distinct familial tumor syndrome that maps to a 22 cM region of chromosome 1

1500-1530: Posters - Coffee

1530-1700: Session 3 - CANCER (1q21)

10.	Anne Forus	Cloning and characterisation of three novel candidate genes from the 1q21 amplicon
11.	Vadim Dyomin	Cloning of two t(1;14)(q21;q32) translocation breakpoints common in Non-Hodgkin's Lymphomas that resulting in aberrant expression of MUC1 and FCGRIIB gene
12.	Mary Callanan	FISH mapping of novel 1q breakpoints in malignant lymphoma; frequent rearrangement of heterochromatin band 1q12 and identification of two distinct but adjacent breakpoint cluster sites in a 2.5Mb region of proximal 1q21
13.	Kimberly Matheson	The proposed chromosomal organization of the RH Locus at 1p36-34 derived from human genome contiguous sequences
14.	Emily Eden	Use of homozygosity mapping to identify a region on chromosome 1 bearing a defective gene that causes autosomal recessive homozygous hypercholesterolaemia in two unrelated families

1700-1730: POSTERS - Coffee

1730-1900: IT Session (II)

 1930: Dinner

Monday, October 2

0830-1000: Session 4 - DISEASES (1p -1q25)

15.	Erik Sulman	Characterization of a tumor suppressor locus on 1p32 in meningioma
16.	Mathilde Varret	Fine mapping of region 1p32-p34.1 that contains the third major locus for Autosomal Dominant Hypercholesterolemia
17.	Francesca Capon	Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21
18.	Takashi Shiina	Physical mapping of 3.7 Mb and genome sequencing of 1.1 Mb in the human chromosome 1q22-q23 region paralogous to the 6p21.3 HLA region: the CD1 genes, new members of olfactory receptor genes and multiple immune-related genes
19.	Sumera Hasham	Characterization of a novel autosomal dominant bleeding disorder in a large kindred from east Texas

1000-1030: POSTERS - Coffee - Workshop Report Meeting

1030-1200: Session 5 - DISEASES (1q32-q41)

20.	Bryan Bjork	Characterization of 41 genes identified through the analysis of 1 Mb of sequence surrounding the Van der Woude syndrome (VWS) critical region at 1q32-q41
21.	Pedro Fernandez	Mapping a cardiac conduction disorder (PFHBII) complicated by DCM to a novel disease-causing locus on chromosome 1q32.1-q41
22.	Katrin Hoffmann	A gene for Pelger Huët anomaly maps to chromosome 1q41-43
23.	Kathryn Ewens	A BAC/PAC contig of a region of chromosome 1q42-q43 containing a putative susceptibility gene for type 1 diabetes
24.	Hal Hoffman	Genetic and physical mapping of the FCU locus on chromosome 1q44

1200: Closing Remarks

1200-1230: POSTERS - Coffee

1230-1330: Lunch

1330-1630: Drive to Devonian Fossil Site and Raptor Center

1630-1700: Refreshments

1700-1730: Workshop Report Meeting

1730-1900: IT Session (III)

1900: Drive to Mennonite Farm for Dinner

 Tuesday 03 October

 Depart