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Report of the Second International Workshop on Human Chromosome 1 Mapping 1995

Publication Reference

Weith A, Brodeur G, Bruns G, Matise T, Mischke D, Nizetic D, Seldin M, van Roy N, Vance J: Report of the second international workshop on human chromosome1 mapping 1995. Cytogenet Cell Genet 72:113-154, 1996.

Report of the Second International Workshop on Human Chromosome 1 Mapping 1995

Andreas Weith (1)*, Garrett M. Brodeur (2), Gail A. P. Bruns (3), Tara Cox Matise (4), Dietmar Mischke (5), Dean Nizetic (6), Michael F. Seldin (7), Nadine van Roy (8), and Jeffery Vance (9)

(1) Research Institute of Molecular Pathology (I.M.P.), Vienna, Austria,
(2) Department of Oncology, Children's Hospital of Philadelphia, Philadelphia PA (USA),
(3) Children's Hospital Medical Center, Genetics Division, Boston MA (USA),
(4) Columbia University, Department of Psychiatry, New York NY (USA),
(5) Institut fur Experimentelle Onkologie und Transplantationsmedizin, Humboldt-Universitat, Berlin, Germany,
(6) The School of Pharmacy, University of London, London, U. K.,
(7) Duke University Medical Center, Durham NC (USA),
(8) Department Medical Genetics, University Hospital Ghent, Ghent, Belgium,
(9) Division of Neurology, Duke University Medical Center, Durham NC (USA)

*to whom correspondence should be sent:
Dr. Andreas Weith, Research Institute of Molecular Pathology, Dr. Bohr Gasse 7, A-1030 Vienna, Austria;
phone: (+43)-1-797 30 625, FAX: (+43)-1-798 71 53, email: weith@aimp.una.ac.at

Introduction

The Second International Chromosome 1 Mapping Workshop was held at the Research Institute of Molecular Pathology (I.M.P.) in Vienna, Austria, between the 22 and 24 September, 1995. A total of 36 invited scientists from 9 different countries attended this meeting. Participating countries were: U.S.A. (16 residents), Germany (5), United Kingdom (5), Austria (3), Netherlands (2), Belgium (2), France (1), Norway (1), and Sweden (1). 34 Posters were presented and discussed. Again, as during the first chromosome 1 workshop, discussion workgroups were constituted to cover the topics of genetic, physical, FISH and comparative mapping, as well as new and disease gene assignment and malignancies. Furthermore, at this workshop a major attempt was made to collect information on resources for mapping projects.

A considerable number of newly assigned loci was reported to come from fluorescent in situ hybridization mapping studies on metaphase chromosomes (FISH). Also a substantial number of new and refined physical maps and - in particular - long clone contigs were reported by several groups. It became obvious again, however, that a chromosome that constitutes approximately 8-10% of the entire genome is difficult to cover by any means to date. In view of integrating the FISH, physical, comparative and genetic data into a comprehensive consensus map, various options were discussed at length at the workshop. The generation of a graphical framework using either the SIGMA program or the facilities of the IGD (Heidelberg, Germany) were preferred as appropriate display forms. Further decisions on the selection will depend on information obtained by Otto Ritter, Heidelberg, who will be contacted on that issue. A core of participants agreed to try two different programs, ACEDB and SIGMA, to decide which will best serve the chromosome 1 community. It was agreed that, as an example of a consensus map, the data obtainable from a limited region of the chromosome (e.g. 1pter-p35) shall be compiled once the database fomat is chosen. This map may be displayed at the new WWW site that has been set in place at Rockefeller University by Tara Cox Matise (see the respective section of the report).

As to one particular detail of this report, the section on new genes contains some redundancy with regard to the FISH mapping section; however, the description of new and newly assigned genes with particular focus on their functional properties is designated valuable particularly with the aspect of possible disease associations. Also, a grouping of a series of chromosome 1 located genes by means of their functional properties (see Table 4) was suggested to be of widespread interest.

There was agreement amongst the workshop delegates that, besides an extensive exchange of data, news and knowledge via the chromosome 1 WWW site there should be another chromosome workshop of a "non-virtual" nature. Preference was given to a smaller meeting with less delegates, e.g. joining only the workshop chairs and chromosome editors. Preliminary plans were made to meet in the fall of 1996 as an adjunct meeting to the ASHG meeting in San Francisco, CA.

For those who will have a continuous interest in chromosome 1 related mapping work, the chromosome 1 web page should be considered a platform of information and exchange. Care will be taken to keep and manage this site appropriately.

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