Figure Legend.

Figure 1: Comprehensive genetic linkage map of 810 loci on chromosome 1. The complete map is here. The (a) p-arm and (b) q-arm are also available separately, with some overlap of markers in the pericentromeric region. All loci are localized to positions with 1000:1 odds or greater. Backbone markers (those that were uniquely localized) are shown on the vertical bar on the left with inter-locus distances in Kosambi centiMorgans. Off-backbone markers are shown in their 1000:1 odds positions, which usually span more than one backbone interval; the thick bar indicates the most likely map interval with odds <1000:1. Some off-backbone markers span only one map interval, indicating they exceeded the error threshold. As the relative order of off-backbone markers sharing the same map interval is not known, such markers are listed in random order. Genes are shown in red, PCR-based anonymous markers are shown in blue, and hybridization-based anonymous markers are shown in green. This map will shortly be submitted to GDB.

Figure 2: Disease map of Chromosome 1

Figure 3: Cancer deletions on Chromosome 1

Figure 4: Cancer translocations on Chromosome 1

Figure 5: Cancer duplications on Chromosome 1

Figure 6: The Sanger Centre strategy for the mapping and sequencing of chromosome 1. Data and/or material moves through the process in the direction of the arrows. There is continuous feedback through the system to ensure data quality is maintained and that each stage of the process is running efficiently. The information from various point in the project is made available via the Internet at http://www.sanger.ac.uk and ftp://ftp.sanger.ac.uk.

Figure 7: The analysis of chromosome 1 sequence produced at the Sanger Centre: Tenascin-R. The figure is a snap-shot of ACeDB showing the analysis of sequence from chromosome 1that includes the Tenascin-R gene. The header at the top of the figure shows the similarity (99%) between an exon of the sequence (bases 4030 to 4671) and the human Tenascin-R cDNA (Accession number Z67996). The sequence runs from the top of the figure (base 1) to the bottom (base 118360). Each column indicates a feature of the sequence: 1, up genes as predicted by fgeneh (coding regions with the amino terminus at the bottom of the page), 2, DNA sequence scale bar shown as 10kb intervals, 3, down genes as predicted by fgeneh (reverse to 1), 4, manually annotated genes (Tenascin-R shown), 5, repeat regions, Alu, Lines , tandem, 6, predicted coding regions (a)BlastX (b)Xpound (c)Grail, 7, region of similarity with other DNA sequences using BlastN, 8, regions of similarity with ESTs.