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Objective
To characterize in detail
the human genomic regions that are most likely to harbor genes that
contribute to susceptibility for schizophrenia, and to use this
characterization to identify and test several strong schizophrenia candidate
genes. There are 3 specific aims.
Aim 1
To identify and fully characterize the
putative schizophrenia candidate gene regions (SCRs) by: (a) extracting
utilizable data from existing genome scans for SZ genes, (b) determining the
SCRs based on significant and/or multiple suggestive linkage findings, (c)
listing and comprehensively describing the genomic elements within each SCR,
and (d) analyzing and comparing the DNA sequences of the SCRs.
Aim 2
To determine the strong SZ candidate genes
by: (a) generating an exhaustive list of putative SZ susceptibility genes
within the SCRs and (b) ranking the list of genes based on the supportive
evidence from Aim 1.
Aim 3
To generate the SZ interactome by: (a)
determining the genes that interact with the exhaustive list of putative SZ
genes and (b) generating an interactome based on existing list of genes and
their interactors.
Principal Investigator
Tara
C. Matise, Ph.D.
Associate Professor, Department of Genetics
Life Sciences Building Rm 122
145 Bevier Road, Piscataway, NJ 08854
732-445-1027 (P) | 732-445-1147 (F)
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