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Objective
To establish a high-throughput bioinformatics approach to identify candidate genes for the Modvl loci. There are 4 specific aims.
Aim 1:
To identify genes within the Modvl 95% confidence intervals (CIs) expressed at particular developmental stages.
Aim 2:
To determine which of these developmentally expressed genes are localized to the developing CNS and eye.
Aim 3:
To identify coding polymorphisms in these CNS- and eye-restricted transcripts and determine whether they are predicted to be functional.
Aim 4:
To demonstrate these developmentally restricted transcripts are associated with pathways relevant to neural tube closure and lens development.
Principal Investigators
Tara C. Matise, Ph.D.
Associate Professor
Department of Genetics, Rutgers University
145 Bevier Road (LSB 122), Piscataway, NJ 08854
848-445-3125 (P) | 732-445-1147 (F)
and
James H. Millonig, Ph.D.
Associate Professor
Center for Advanced Biotechnology and Medicine
679 Hoes Lane, Piscataway, NJ 08854
732-235-3391 (P) | 732-235-4850 (F)