Schizophrenia Candidate Gene Regions: References
Genome Scans
G01
Coon H, Jensen S, Holik J, Hoff M, Myles-Worsley M, Reimherr F, Wender P, Waldo M, Freedman R, Leppert M, and Byerley W (1994) Genomic scan for genes predisposing to schizophrenia. Am J Hum Genet (Neuropsychiatr Genet). 54:59-71.
PMID: 7909992
G02
Barr CL, Kennedy JL, Pakstis AJ, Wetterberg L, Sjogren B, Bierut L, Wadelius C, Wahlstrom J, Martinsson T, Giuffra L, Gelernter J, Hallmayer J, Moises HW, Kurth J, Cavalli-Sforza LL, and Kidd KK (1994) Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred. Am J Med Genet. 54(1):51-58.
PMID: 7909991
G03
Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, Kimberland M, Babb R, Vourlis S, Chen H, Lalioti M, Morris MA, Karayiorgou M, Ott J, Meyers D, Antonarakis SE, Housman D, and Kazazian HH (1995) Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet. 60(3):252-260.
PMID: 7573181
G04
Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjogren B, Aschauer HN, Hwu H-G, Jang K, Livesley WJ, Kennedy JL, Zoega T, Ivarsson O, Bui M-T, Yu M-H, Havsteen B, Commenges D, Weissenbach J, Schwinger E, Gottesman II, Pakstis AJ, Wetterberg L, Kidd KK, and Helgason T (1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 11(3): 321-324 (Letter)
PMID: 7581457
G05
Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, Walters MK, Lennon DP, Jones HL, Nertney DA, Daly MJ, Gladis M, and Mowry BJ (1998) Genome scan of schizophrenia. Am J Psychiatry. 155(6): 741-750.
PMID: 9619145
G06a
Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, Meyer J, Zambuto CT, Schmitt K, Matise TC, Harkavy Friedman JM, Hampe C, Lee H, Shore D, Wynne D, Faraone SV, Tsuang MT, and Cloninger CR (1998) NIMH Genetics Initiative Millennium Schizophrenia Consortium: Linkage analysis of African-American pedigrees. Am J Hum Genet (Neuropsychiatr Genet). 81:282-289.
PMID: 9674972
G06b/G07b
Takahashi S, Faraone SV, Lasky-Su J, and Tsuang MT (2005) Genome-wide scan of homogeneous subtypes of NIMH genetics initiative schizophrenia families. Psychiatry Res 133(2-3): 111-22.
PMID: 15740987
G07a
Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B, Hampe C, Zambuto CT, Schmitt K, Meyer J, Markel P, Lee H, Harkavy-Friedman J, Kaufmann C, Cloninger CR, and Tsuang MT (1998) Genome scan of European-American schizophrenia pedigrees: Results for the NIMH Genetics Initiative and Millennium Consortium. Am J Hum Genet (Neuropsychiatr Genet). 81:290-295.
PMID: 9674973
G08a
Blouin J-L, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gehrig C, Radhakrishna U, Snyder SE, Balk KG, Neufeld K, Swartz KL, DeMarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman DE, Kazazian HH, Antonarakis SE, and Pulver AE (1998) Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nature America Inc. 4p (Letter)
PMID: 9731535
G08b
Pulver AE, Mulle J, Nestadt G, Swartz KL, Blouin JL, Dombroski B, Liang KY, Housman DE, Kazazian HH, Antonarakis SE, Lasseter VK, Wolyniec PS, Thornquist MH, and McGrath JA (2000) Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry. 5(6):650-653.
PMID: 11126395
G09
Rees MI, Fenton I, Williams NM, Holmans P, Norton N, Cardno A, Asherson P, Spurlock G, Roberts E, Parfitt E, Mant R, Vallada H, Dawson E, Li MW, Collier DA, Powell JF, Nanko S, Gill M, McGuffin P, and Owen MJ (1999) Autosome search for schizophrenia susceptibility genes in multiply affected families. Mol Psychiatr 4:353-359.
PMID: 10483052
G10
Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Ollikainen V, Arajarvi R, Juvonen H, Kokko-Sahin ML, Vaisanen L, Mannila H, Lonnqvist J, and Peltonen L (1999) A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet. 65(4):1114-24. Comment in: Am J Hum Genet. 67(1):258-259.
PMID: 10486331
G11
Ekelund J, Lichtermann D, Hovatta I, Ellonen P, Suvisaari J, Terwilliger JD, Juvonen H, Varilo T, Arajarvi R, Kokko-Sahin ML, Lonnqvist J, and Peltonen L (2000) Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet. 9(7): 1049-1057.
PMID: 10767329
G12
Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, and Bassett AS (2000) Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science. 288(5466):678-682.
PMID: 10784452
G13
Schwab SG, Hallmayer J, Albus M, Lerer B, Eckstein GN, Borrmann M, Segman RH, Hanses C, Freymann J, Yakir A, Trixler M, Falkai P, Rietschel M, Maier W, and Wildenauer DB (2000) A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6. Mol Psychiatry. 5(6):638-649.
PMID: 11126394
G14a
Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Gebhardt C, Gerhard E, Fuchs K, Sieghart W, Kasper S, Hornik K, and Aschauer HN (2000) Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology. 42(4):175-182.
PMID: 11096332
G14b
Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, Heiden A, Gebhardt C, Doge E, Fuchs K, Sieghart W, Kasper S, Hornik K, and Aschauer HN (2002) Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biol Psychiatry. 52(1):40-52.
PMID: 12079729
G15
Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, and Curtis D (2001) Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet. 68(3):661-673.
PMID: 11179014
G16
Lindholm E, Ekholm B, Shaw S, Jalonen P, Johansson G, Pettersson U, Sherrington R, Adolfsson R, and Jazin E (2001) A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet. 69(1):96-105. Epub 2001 May 25.
PMID: 11389481
G17
Garver DL, Holcomb J, Mapua FM, Wilson R, and Barnes B (2001) Schizophrenia spectrum disorders: an autosomal-wide scan in multiplex pedigrees. Schizophr Res. 52(3):145-160.
PMID: 11705708
G18
Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JA, Rinard K, Foti A, Terwilliger JD, Juvonen H, Suvisaari J, Arajarvi R, Suokas J, Partonen T, Lonnqvist J, Meyer J, and Peltonen L (2001) Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet. 10(26):3037-3048.
PMID: 11751686
G19
DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW, Wellman N, Loftus J, Nanthakumar B, Razi K, Stewart J, Comazzi M, Vita A, Heffner T, and Sherrington R. (2002a). A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry. 159(5):803-812.
PMID: 11986135
G20
Straub RE, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, O'Neill FA, Walsh D, and Kendler KS (2002) Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. Mol Psychiatry. 7(6):542-559.
PMID: 12140777
G21
DeLisi LE, Mesen A, Rodriguez C, Bertheau A, LaPrade B, Llach M, Riondet S, Razi K, Relja M, Byerley W, and Sherrington R (2002b) Genome-wide scan for linkage to schizophrenia in a Spanish-origin cohort from Costa Rica. Am J Med Genet. 114(5):497-508.
PMID: 12116183
G22
Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, and Stefansson K (2002) Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet. 71(4):877-892. Epub 2002 Jul 23.
PMID: 12145742
G23
Lerer B, Segman RH, Hamdan A, Kanyas K, Karni O, Kohn Y, Korner M, Lanktree M, Kaadan M, Turetsky N, Yakir A, Kerem B, and Macciardi F (2003) Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol Psychiatry. 8(5):488-498.
PMID: 12808429
G24
Arinami T, Ishiguro H, Minowa Y, Ohtsuki T, Tsujita T, Imamura A, Yoshikawa T, Toyota T, Yamada K, Shimizu H, Yoshitsugu K, Shibata H, Fujii Y, Fukumaki Y, Tashiro N, Inada T, Iijima Y, Kitao Y, Furuno T, Someya T, Muratake T, Kaneko N, Tsuji S, Mineta M, Takeichi M, Ujike H, Takehisa Y, Tanaka Y, Nakata K, Kitajima T, Nishiyama T, Yamanouchi Y, Iwata N, Ozaki N, Ohara K, Shibuya H, Ohara K, Suzuki Y, Ohmori O, Shinkai T, Hori H, Nakamura J, Kojima T, Takahashi S, Tanabe T, Yara K, Nanko S, Yoneda H, Koh J, Sakai J, Inada Y, Kusumi I, Kameda K, Koyama T, Fukuzako H, Hashiguchi T, Tanabe K, and Okazaki Y (2003) Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) families. Am J Med Genet B Neuropsychiatr Genet. 120(1):22-28.
PMID: 12815734
G25
Wijsman EM, Rosenthal EA, Hall D, Blundell ML, Sobin C, Heath SC, Williams R, Brownstein MJ, Gogos JA, Karayiorgou M (2003) Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: evidence for linkage to chromosome 2q. Mol Psychiatry. 8(7):695-705.
PMID: 12874606
G26
Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang KY, and Pulver AE (2003) Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22. Am J Hum Genet. 73(3):601-611. Epub 2003 Aug 15.
PMID: 12929083
G27
Williams NM, Norton N, Williams H, Ekholm B, Hamshere ML, Lindblom Y, Chowdari KV, Cardno AG, Zammit S, Jones LA, Murphy KC, Sanders RD, McCarthy G, Gray MY, Jones G, Holmans P, Nimgaonkar V, Adolfson R, Osby U, Terenius L, Sedvall G, O'Donovan MC, and Owen MJ (2003) A systematic genomewide linkage study in 353 sib pairs with schizophrenia. Am J Hum Genet. 73(6):1355-1367. Epub 2003 Nov 18.
PMID: 14628288
G28
Sklar P, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, Morley CP, Kennedy JL, Azevedo MH, Lander E, Daly MJ, and Pato CN (2004) Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis. Mol Psychiatry. 9(2):213-218.
PMID: 14699422
G29
Abecasis GR, Burt RA, Hall D, Bochum S, Doheny KF, Lundy SL, Torrington M, Roos JL, Gogos JA, and Karayiorgou M (2004) Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. Am J Hum Genet. 74(3):403-417. Epub 2004 Jan 28.
PMID: 14750073
G30
Maziade M, Roy MA, Chagnon YC, Cliche D, Fournier JP, Montgrain N, Dion C, Lavallee JC, Garneau Y, Gingras N, Nicole L, Pires A, Ponton AM, Potvin A, Wallot H, Merette C (2005) Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families. Mol Psychiatry. 10(5):486-499.
PMID: 15534619
G31
Klei L, Bacanu SA, Myles-Worsley M, Galke B, Xie W, Tiobech J, Otto C, Roeder K, Devlin B, Byerley W (2005) Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia. Hum Genet. 117(4):349-356. Epub 2005 May 25.
PMID: 15915326
G32
Hamshere ML, Bennett P, Williams N, Segurado R, Cardno A, Norton N, Lambert D, Williams H, Kirov G, Corvin A, Holmans P, Jones L, Jones I, Gill M, O'Donovan MC, Owen MJ, and Craddock N (2005) Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry 62(10): 1081-8.
PMID: 16203953
G33
Suarez BK, Duan J, Sanders AR, Hinrichs AL, Jin CH, Hou C, Buccola NG, Hale N, Weilbaecher AN, Nertney DA, Olincy A, Green S, Schaffer AW, Smith CJ, Hannah DE, Rice JP, Cox NJ, Martinez M, Mowry BJ, Amin F, Silverman JM, Black DW, Byerley WF, Crowe RR, Freedman R, Cloninger CR, Levinson DF, and Gejman PV (2006) Genomewide linkage scan of 409 European-Ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am J Hum Genet 78(2): 315-33.
PMID: 16400611
G34
Faraone SV, Hwu HG, Liu CM, Chen WJ, Tsuang MM, Liu SK, Shieh MH, Hwang TJ, Ou-Yang WC, Chen CY, Chen CC, Lin JJ, Chou FH, Chueh CM, Liu WM, Hall MH, Su J, Van Eerdewegh P, and Tsuang MT (2006) Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3. Am J Psychiatry 163(10): 1760-6.
PMID: 17012687
G35
Vazza G, Bertolin C, Scudellaro E, Vettori A, Boaretto F, Rampinelli S, De Sanctis G, Perini G, Peruzzi P, and Mostacciuolo ML (2007) Genome-wide scan supports the existence of a susceptibility locus for schizophrenia and bipolar disorder on chromosome 15q26. Mol Psychiatry 12(1): 87-93.
PMID: 16969366
G36
Bulayeva KB, Glatt SJ, Bulayev OA, Pavlova TA, and Tsuang MT (2007) Genome-wide linkage scan of schizophrenia: a cross-isolate study. Genomics 89(2): 167-77.
PMID: 17140763
G37
Escamilla MA, Ontiveros A, Nicolini H, Raventos H, Mendoza R, Medina R, Munoz R, Levinson D, Peralta JM, Dassori A, and Almasy L (2007) A genome-wide scan for schizophrenia and psychosis susceptibility loci in families of Mexican and Central American ancestry. Am J Med Genet B Neuropsychiatr Genet 144(2): 193-9.
PMID: 17044102
G38
Teltsh O, Kanyas K, Karni O, Levi A, Korner M, Ben-Asher E, Lancet D, Hamdan A, Lerer B, and Kohn Y (2008) Genome-wide linkage scan, fine mapping, and haplotype analysis in a large, inbred, Arab Israeli pedigree suggest a schizophrenia susceptibility locus on chromosome 20p13. Am J Med Genet B Neuropsychiatr Genet 147B(2): 209-15.
PMID: 17823922
Meta-Analyses
A01
Badner JA and Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7(4): 405-11.
PMID: 11986984
A02
Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lonnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoega T, and Helgason T (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 73(1): 34-48.
PMID: 12802786
Microarray Studies
M01a
Mirnics K, Middleton FA, Marquez A, Lewis DA, and Levitt P (2000) Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28(1): 53-67.
PMID: 11086983
M01b
Mirnics K, Middleton FA, Stanwood GD, Lewis DA, and Levitt P (2001) Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 6(3): 293-301.
PMID: 11326297
M01c
Middleton FA, Mirnics K, Pierri JN, Lewis DA, and Levitt P (2002) Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 22(7): 2718-29.
PMID: 11923437
M02
Hakak Y, Walker JR, Li C, Wong WH, Davis KL, Buxbaum JD, Haroutunian V, and Fienberg AA (2001) Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 98(8): 4746-51.
PMID: 11296301
M03
Vawter MP, Barrett T, Cheadle C, Sokolov BP, Wood WH, 3rd, Donovan DM, Webster M, Freed WJ, and Becker KG (2001) Application of cDNA microarrays to examine gene expression differences in schizophrenia. Brain Res Bull 55(5): 641-50.
PMID: 11576761
M04
Kuromitsu J, Yokoi A, Kawai T, Nagasu T, Aizawa T, Haga S, and Ikeda K (2001) Reduced neuropeptide Y mRNA levels in the frontal cortex of people with schizophrenia and bipolar disorder. Brain Res Gene Expr Patterns 1(1): 17-21.
PMID: 15018814
M05
Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, and Bahn S (2002) Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Proc Natl Acad Sci U S A 99(7): 4680-5.
PMID: 11930015
M06
Hemby SE, Ginsberg SD, Brunk B, Arnold SE, Trojanowski JQ, and Eberwine JH (2002) Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex. Arch Gen Psychiatry 59(7): 631-40.
PMID: 12090816
M07
Vawter MP, Crook JM, Hyde TM, Kleinman JE, Weinberger DR, Becker KG, and Freed WJ (2002) Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study. Schizophr Res 58(1): 11-20.
PMID: 12363385
M08
Chung C, Tallerico T, and Seeman P (2003) Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene. Synapse 50(1): 29-34.
PMID: 12872291
M09a
Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, Starkey M, Webster MJ, Yolken RH, and Bahn S (2003) Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362(9386): 798-805.
PMID: 13678875
M09b
Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, and Bahn S (2004) Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 9(7): 684-97, 643.
PMID: 15098003
M10
Vawter MP, Ferran E, Galke B, Cooper K, Bunney WE, and Byerley W (2004) Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree. Schizophr Res 67(1): 41-52.
PMID: 14741323
M11
Aston C, Jiang L, and Sokolov BP (2004) Microarray analysis of postmortem temporal cortex from patients with schizophrenia. J Neurosci Res 77(6): 858-66.
PMID: 15334603
M12
Sugai T, Kawamura M, Iritani S, Araki K, Makifuchi T, Imai C, Nakamura R, Kakita A, Takahashi H, and Nawa H (2004) Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression. Ann N Y Acad Sci 1025: 84-91.
PMID: 15542704
M13
Iwamoto K, Bundo M, and Kato T (2005) Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 14(2): 241-53.
PMID: 15563509
M14a
Tsuang MT, Nossova N, Yager T, Tsuang MM, Guo SC, Shyu KG, Glatt SJ, and Liew CC (2005) Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 133(1): 1-5.
PMID: 15645418
M14b
Glatt SJ, Everall IP, Kremen WS, Corbeil J, Sasik R, Khanlou N, Han M, Liew CC, and Tsuang MT (2005) Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Proc Natl Acad Sci U S A 102(43): 15533-8.
PMID: 16223876
M15a
Katsel P, Davis KL, Gorman JM, and Haroutunian V (2005a) Variations in differential gene expression patterns across multiple brain regions in schizophrenia. Schizophr Res 77(2-3): 241-52.
PMID: 15923110
M15b
Katsel P, Davis KL, and Haroutunian V (2005b) Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study. Schizophr Res 79(2-3): 157-73.
PMID: 16139990
M16
Altar CA, Jurata LW, Charles V, Lemire A, Liu P, Bukhman Y, Young TA, Bullard J, Yokoe H, Webster MJ, Knable MB, and Brockman JA (2005) Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol Psychiatry 58(2): 85-96.
PMID: 16038679
M17
Middleton FA, Pato CN, Gentile KL, McGann L, Brown AM, Trauzzi M, Diab H, Morley CP, Medeiros H, Macedo A, Azevedo MH, and Pato MT (2005) Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet 136(1): 12-25.
PMID: 15892139
M18
Mexal S, Frank M, Berger R, Adams CE, Ross RG, Freedman R, and Leonard S (2005) Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers. Brain Res Mol Brain Res 139(2): 317-32.
PMID: 16122832
M19
McCurdy RD, Feron F, Perry C, Chant DC, McLean D, Matigian N, Hayward NK, McGrath JJ, and Mackay-Sim A (2006) Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophr Res 82(2-3): 163-73.
PMID: 16406496
M20
Bowden NA, Weidenhofer J, Scott RJ, Schall U, Todd J, Michie PT, and Tooney PA (2006) Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia. Schizophr Res 82(2-3): 175-83.
PMID: 16414245
M21
Arion D, Unger T, Lewis DA, Levitt P, and Mirnics K (2007) Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 62(7): 711-21.
PMID: 17568569
M22
Dean B, Keriakous D, Scarr E, and Thomas EA (2007) Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia. Aust N Z J Psychiatry 41(4): 308-20.
PMID: 17464717
Association Studies
Allen NC, Bagade S, Tanzi R, and Bertram L (2007) "Schizophrenia Research Forum: The SchizophreniaGene Database." Retrieved 15 January 2008, from http://www.schizophreniaforum.org/res/sczgene/default.asp, which is now http://www.szgene.org/.
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Kong X, Murphy K, Raj T, He C, White PS, and Matise TC (2004) A combined linkage-physical map of the human genome. Am J Hum Genet 75(6): 1143-8.
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Matise TC, Chen F, Chen W, De La Vega FM, Hansen M, He C, Hyland FCL, Kennedy GC, Kong X, Murray SS, Ziegle JS, Stewart WCL, and Buyske S (2006) A second-generation combined linkage-physical map of the human genome.Genome Res 17(12): 1783-6.
PMID: 17989245
Chen F, He C, Kong X, Chen W, Hansen M, Hyland FCL, Kennedy GC, Murray SS, Turpaz Y, De La Vega FM, Ziegle JS, and Matise TC (2006) A second-generation combined linkage-physical map of the human genome. Presented at the 56th Annual Meeting of The American Society of Human Genetics, New Orleans, LA. Available from http://www.ashg.org/genetics/ashg06s/index.shtml.
