This application allows the prioritization of genes within schizophrenia candidate gene regions (SCRs), specifically within subregions, by assigning weights to various parameters specified below. The genetic locations of the SCRs were projected onto the high resolution Rutgers third-generation combined linkage-physical map (Rutgers Map v.3). You may change the weights assigned to the different parameters and indicate the cut-off based on the weights before running SchizPrioritizer.
The values of x for the SCR subregions below correspond to the maximum -log10(p-values) that we have calculated from our simulations as part of our smoothing method. A higher value of x corresponds to a higher LOD score obtained from our integrated analysis of 47 independent genomewide linkage scans for SZ. "Outside" a specific genetic element (e.g., segmental duplication), includes region 10kb upstream or downstream of that element. The percentage (%) cut-off will be used to determine the exact cut-off score for the genes that will be included in the output file. This means that if other genes below the percentage cut-off have the same overall score as the gene at the cut-off %, we will include those genes in the results page.
Note: This page is still under construction. This will be available soon.